The Ducati 749 is a 90° V-twin Desmodromic valve actuated engine sport bike built by Ducati Motor Holding between 2003 and 2007.

The 749S model, like the 999, incorporates features rarely found on production motorcycles, including adjustable rake (23.5° or 24.5°) and five-position adjustable rearset mounts.

A limited number of the 749 were manufactured as a race version — the 749R — each with their production number stamped on the triple clamp – and initially cost almost twice the original 749 base model.

This race model was lighter, had a shorter stroke, increased bore and larger valves which allowed it to run more efficiently at higher RPM, and hence, produced more torque and power than the 749/S models.

The 749R also came with a larger fuel tank (18.3 L or 4.0 imp gal or 4.8 US gal); slipper clutch; Öhlins forks, shock and steering damper; racing cams; titanium valves, valve guides, and connecting rods; magnesium head covers, and carbon fiber belt covers.