Ducati first showed a final production version of the bike at a press day for the '06 Italian Grand Prix at Mugello.

Priority for ordering was given to Ducati 999R owners, with production projected at one bike per day at a retail cost of US$72,500[5] and £40,000.

[6] The price included a three-year warranty and servicing, cover, and a racing kit including a race-only exhaust system, a slip-on muffler, and complementary fuel and ignition mapping in a "race ECU".

With forged magnesium wheels the Desmosedici RR was the first Ducati production bike to use them.

Aprilia used them in 2002 on their limited edition RSV Mille SP The Ducati Desmosedici RR production started beginning in October 2007 till December 2008, and the first customer orders delivered from January 2008.