Ducati said the Panigale V4 was designed to combine racing features, while also being an entertaining and rideable motorcycle with a durable engine.

[7] Originally, Ducati was initially keeping the MotoGP bike's chassis, but later changed to a completely new front frame they said has less weight and more stability.

[11] The bike's tires, the Diablo Super Corsa SP developed by Ducati and Pirelli, have a new rear compound.

It has an Öhlins suspension that the rider can electronically adjust, or set to the sport, race, or street modes typical of contemporary performance bikes.

[citation needed] The Panigale V4 Speciale has the S model options, and adds adjustable footpads, an Alcantara-trimmed seat, a top triple clamp,[clarification needed] carbon mudguards, a data analyzer system, and race fuel cap.

This makes the V4 R the most powerful current street-legal production bike available in the world, meaning that, with a dry weight of 167 kg, reaches a power-to-weight ratio of 1.42.

According to the Ducati CEO Claudio Domenicali, the winglets applied to the V4 R fairing are almost identical to the GP16 MotoGP bike.

This makes the V4 Superleggera the most powerful street-legal production bike available in the world, meaning that, with a dry weight of 152,2 kg, reaches a power-to-weight ratio of 1.56.