In addition to the standard model, an upgraded Streetfighter S was available, equipped with Öhlins suspension components, Marchesini forged wheels and parts made of carbon fibre-reinforced plastic.

With higher handlebars, wider footrests and a modified seating position, it was aimed at a clientele preferring a less extreme design than that of the larger Streetfighter.

[6] French rider Eric Piscione won the inaugural Motorcycle Middleweight Division race at the 2014 Pikes Peak International Hill Climb with the Streetfighter 848.

[8] As with its technical basis, the Panigale V4 sport bike, it utilizes the Desmosedici Stradale 90° V4 engine with a displacement of 1103 cm3.

[8][11] The Streetfighter V2, announced in November 2021 and released for sale in 2022, is modified from the Panigale V2 sport bike.