She was married to His Royal Highness Crown Prince Frederick, heir apparent to the Danish throne, in Neustrelitz on 10 June 1841.

[1] Very early on, the marriage proved to be a very unhappy one, due in large part to The Crown Prince's bad temperament, excessive drinking and shameless womanizing.

Princess Caroline Mariane, who was described as incurably shy and nervous, lacked the ability to serve as a calming influence over her consort.

Following the divorce, Caroline Marianne, who retained her title, lived a quiet life in Neustrelitz.

She died quietly in Neustrelitz on 1 June 1876 and was buried in Johanniterkirche, Mirow, Mecklenburgische Seenplatte, Mecklenburg-Vorpommern, Germany.