The following year he defended an attack from Prospero Colonna, but lost Esperia and Monte San Giovanni Campano until Pope Alexander VI recognised him as duke.
After defending his lands from Cesare Borgia's assault, in 1516 Francesco Maria was ousted by Fernando d'Avalos, acting for the king of Naples, Charles IV.
The creation of an independent state in southern Lazio had been managed by cardinal Francesco Maria Del Monte to counterbalance the expansion of the House of Farnese.
They also founded a new town, Colle Drago, but after Giacomo and his successor Gregorio I, the financial difficulties of the family, caused by such expensive projects, prevented further efforts.
At the death of duke Giovan Giacomo (1636), his brother Ugo had to face the popular rebellion of the brigand Papone, a follower of the republicanism of Masaniello.
The union of the Boncompagni and Ludovisi families as the Boncompagni-Ludovisi largely resolved their economical difficulties, but at that time the duchy was facing increased custom taxes imposed by the Papal States on its merchants.
Gregorio II's successor, Antonio I, died in 1731, leaving his lands to his son Gaetano, who relaunched a policy of social and economical improvements in the Liri Valley, as well as the embellishment of Colle Drago.