[2] In 1917 Noble became the head football coach at the University of Mississippi (Ole Miss), a position he held for two seasons.

During his two years as the Rebels' head coach he compiled a record of 2–7–1 and went 0–3 against his alma mater, Mississippi A&M.

As head baseball coach he compiled a record 267–201–9 and won three Southern Intercollegiate Athletic Association championships.

[7] Noble also served one season as the Bulldogs' head football coach going 3–4–2 in 1922, including a victory over his former squad from Ole Miss.

[5][13] Speaking on his time spent in Oxford Dudy Noble once told a Tennessee sports writer: “I already know what hell is like.

I once coached at Ole Miss.”[14] Noble once owned a bird dog, a lazy mutt that refused to hunt.