[7] Cannizaro singled in the first at-bat of his career on September 8, 2006, against Brian Burres of the Baltimore Orioles, and later scored.

He hit his first major league home run on September 25, 2006, off Jon Switzer in a 16–1 win against the Tampa Bay Devil Rays.

[10] On November 5, 2016, Mississippi State University Athletic Director John Cohen, who had recently stepped down as head baseball coach, announced Cannizaro as his successor.

Lee Cannizaro attended the University of Southern Mississippi where he played college baseball.

His youngest brother, Garrett Cannizaro, 27, attended Tulane University where he played baseball.