The Duff Barn is a historic building located on a farm north of Winterset, Iowa, United States.

Silas Barnes bought 160 acres (65 ha) in 1847, and received the deed in 1850.

It is attributed to David Harris because the following elements of his work are found here: a rectangle plan that is asymmetrically massed, two-against-one broken bond, and textured surfaces on the quoins, jambs and lintels.

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