The William Anzi Nichols House is a historic residence located east of Winterset, Iowa, United States.

Nichols bought an 80 acres (32 ha) farm in 1855 and owned the land until he died in 1867.

The 1½-story structure is composed of locally quarried finished cut and rubble limestone.

Its construction is attributed to David Harris who was known for laying the stones in a two against one broken bond.

This article about a property in Madison County, Iowa on the National Register of Historic Places is a stub.