Duke of Seville (Spanish: Duque de Sevilla) is a title of Spanish nobility that was granted in 1823 by King Ferdinand VII of Spain to his nephew, Infante Enrique of Spain.

The Dukes of Seville are members of the Spanish branch of the House of Bourbon, and they are also Grandees of Spain.

Since 22 October 1968, the holder of the ducal title has been Don Francisco de Borbón y Escasany, 5th Duke of Seville.

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