Dumitru Bagdasar specialized in Neurosurgery at the famous Peter Bent Brigham clinic of Dr. Harvey Cushing.

[3] Returning to the Romania in 1929, Doctors Dumitru and Florica Bagdasar encountered difficulties from the state authorities and were assigned to the outskirts of the country.

in 1935, Bagdasar managed to establish a small neurosurgery service, with ten beds and a single operating room, in the Central Hospital for Nervous and Mental Diseases in Bucharest.

[4] Dedicated to social issues his adolescence, he was acutely aware of the impoverished condition of the Moldovan peasant such malnutrition, astronomical infant mortality, illiteracy, lack of hygiene and medical care, which led to him collaborating with left-wing groups.

During the Second World War, he was an active part of the leadership of the "Union of Patriots" in 1942, then of the "National Popular Party".

In April 1944 he was one of the initiators of the intellectuals' manifesto addressed to Marshal Antonescu, which demanded Romania's exit from the war.