Born in Leicester, Fegredo first managed to get into comics after showing his portfolio around UKCAC in 1987 and meeting Dave Thorpe.
He then worked with writer Peter Milligan on Enigma, an eight-issue miniseries for DC's Vertigo imprint.
Other work includes the comic-book versions of Kevin Smith's Jay and Silent Bob characters, Shade the Changing Man and Ultimate Adventures For a few years, Duncan Fegredo was the regular artist on Dark Horse's Hellboy series.
With Guinness officials on hand to monitor their progress, writer Mark Millar began work at 9am scripting a 20-page black and white Superior comic book, with Fegredo and the other artists appearing on stage throughout the day to work on the pencils, inks, and lettering, including Dave Gibbons, Frank Quitely, John Romita Jr., Jock,[4] Doug Braithwaite, Ian Churchill, Olivier Coipel, Simon Furman, David Lafuente, John McCrea, Sean Phillips and Liam Sharp,[5] who all drew a panel each, with regular Superior artist Leinil Yu creating the book's front cover.
The book was completed in 11 hours, 19 minutes, and 38 seconds, and was published through Icon on 23 November 2011, with all royalties being donated to Yorkhill Children's Foundation.