The Duquesne Brewing Company was a major brewery in Pittsburgh, Pennsylvania, from its founding in 1899 until its dissolution in 1972.

The brand was revived under the name Duquesne Brewing Company in 2008, in order to re-establish the beer in Western Pennsylvania starting in the summer of 2010.

[2] The brewery decided to use refrigerated train cars to ship the beer, an innovative move in the early twentieth century.

The money that Epstein netted from the sale enabled him to found the General American Transportation Corporation.

Duquesne's production capacity increased to two million barrels after World War II when a new building opened at the South Side site in 1950,[6] making it one of the top ten breweries in the United States.

[8] The curved profile of the 1950 building at Plant 1 was to accommodate the PRR Whitehall Branch, which serviced the brewery from sidings along and off Mary Street.

The Friday family, longtime stewards of the brand, would lose control to investor Raymond Sigesmund in a stock battle in 1966.

Schmidt brewed Duquesne in Cleveland into the 1980s, but sales fell drastically after Allegheny County commissioner Thomas Foerster called for a boycott of out-of-town beers; by the very end of the beer's production, the packaging was even changed to look like Schmidt's.

The Duquesne Brewery is distinguishable from other buildings on Pittsburgh's South Side by its large clock, visible from throughout the city.