He has played in Major League Baseball (MLB) for the New York Yankees, Oakland Athletics and Pittsburgh Pirates.

Fowler played in 2014 with the Charleston RiverDogs where he compiled a .257 batting average with nine home runs and 41 RBIs in 66 games.

[6] Fowler received a non-roster invitation to spring training in 2016 and played that season with the Trenton Thunder[7][8] where he batted .281 with 12 home runs, 88 RBIs, and 25 stolen bases in 132 games.

On June 29, Fowler was promoted to the majors[15] and he made his debut that day after a nearly three-hour rain delay, with the Yankees facing the Chicago White Sox on the road.

[16] During the first inning, he ran into a rail while chasing a fly ball, hitting his knee on a sharp edge of an electrical box.

[17][18] On July 31, 2017, the Yankees traded Fowler to the Oakland Athletics, along with fellow prospects Jorge Mateo and James Kaprielian, for starting pitcher Sonny Gray.

[19] On December 15, 2017, Fowler sued the White Sox and the Illinois state agency that manages their ballpark, Guaranteed Rate Field, for allegedly causing his June 29 injury.

His lawsuit, which was filed in the Circuit Court of Cook County, according to the Chicago Sun-Times, claimed negligence on the part of the White Sox and the Illinois Sports Facilities Authority in not properly securing the unpadded electrical box he crashed into.

[23] He started his first game for Oakland on May 11, and got his first major league hit off Yankee pitcher Sonny Gray, the player he was traded for.

[33] After starting the season batting .171/.239/.195 with no home runs and two RBIs in 18 games, Fowler was designated for assignment when Todd Frazier was added to the roster on April 22.