During his senior year at Lafayette Jefferson High School he was the state's leading wide receiver in football with 114 receptions in 2002, was second-team All-State as a small forward in basketball, and he was the high jump state champion in Indiana, clearing 6 ft 9 in in a steady rain after coming second to the Philadelphia 76ers' Rodney Carney with a jump of 6'10".

Keller was named one of top 50 receivers in nation by Street & Smith's and first-team all-state as senior after setting state records with 113 receptions and 1,804 yards (16.0 average) with 22 touchdowns.

[citation needed] During his freshman year at Purdue, Keller red-shirted and switched from wide receiver to tight end.

After a year of watching, learning, and getting stronger, Dustin began to display his strength and athleticism.

Keller was slowly phased into the offense alongside the veteran quarterback Brett Favre.

Keller finished a strong rookie season with 48 receptions, 535 yards and 3 touchdowns.

After not missing a game or a practice in his first four years in the NFL, a pulled groin and high ankle sprain hindered Keller's production in the 2012 regular season, limiting him to 28 receptions for 317 yards and two touchdowns in only 8 games.