Dutchtown is a census-designated place (CDP) and former village in Cape Girardeau County, Missouri, United States, located at the intersection of Routes 25 and 74.

Martin Rodner, a Hessian soldier who came to America in 1776 to fight for the British during America's Revolutionary War, moved his family to the Dutchtown area in 1801, where he owned a water mill on Hubble Creek.

In the mid-1830s, the area near Rodney's Mill began being settled by Swiss and German families; they called their settlement Spencer.

In 1799, the first Protestant sermon and baptism immersion west of the Mississippi River was performed in Randol Creek near modern-day Dutchtown.

[4] In 1836 the German Evangelical Church was founded and remained an active congregation until about 1900.

Dutchtown was incorporated in February 1998 following a petition created by residents, and was disincorporated on 15 March 2018, following continuous flooding problems.

[5] The constant flooding (which occurred in 1973, 1993, 1995, 1998, 2002, 2011, 2013, 2016 and 2017) caused several people to already seek federal buyouts, and all of Dutchtown's assets will be handed over to the county.

[6] According to the United States Census Bureau, the village has a total area of 0.52 square miles (1.35 km2), all land.

The racial makeup of the village was 93.62% White, 2.13% Black or African American, and 4.26% from two or more races.