Millersville is an unincorporated community in western Cape Girardeau County, Missouri, United States.

[3] It is located six miles (10 km) west of Jackson on Route 72.

Millersville is part of the Cape Girardeau–Jackson, MO-IL Metropolitan Statistical Area.

[6] The Miller-Seabaugh House and Dr. Seabaugh Office Building was listed on the National Register of Historic Places in 1996.

This Cape Girardeau County, Missouri state location article is a stub.