Duygu Sag is a Turkish immunologist who contributed to the understanding of the human immune system's fight against cancer.
[1][2][3][4][5] Sag's research centers on harnessing the immune system's potential to combat cancer by targeting specific tumor-associated macrophages.
[2] Her team identified that macrophages lacking the cholesterol transporter ABCG1 exhibit a transformative shift, becoming potent tumor-fighting agents and impeding bladder cancer progression in preclinical studies.
[2] The eventual goal is elucidating the molecular mechanisms underlying this critical macrophage switch, with the potential to pave the way for innovative immunotherapeutic approaches in cancer treatment.
[6] Then she returned to Turkey, becoming a faculty member at Izmir Biomedicine and Genome Center within Dokuz Eylul University.