The plot follows the main ninja characters as they search for the video game's creator following its re-emergence in Ninjago City.

[2] Co-creator Tommy Andreasen stated on Twitter that Prime Empire was inspired by the urban legend Polybius, a fictitious 1980s arcade game.

[32] The season premiered on Cartoon Network on 19 July 2020 with the first episode titled Would You Like to Enter Prime Empire?

[N 4] Inside one of the game zones, a Samurai named Okino faces a crisis of faith when he repeatedly fails to lead a series of Masters to victory, causing him to lose all hope - until some familiar ninja arrive.

[N 7] Once reunited with Jay, the ninja travel across three game zones to obtain three Key-Tanas, which unlock the final challenge at the Temple of Madness.

In the first game zone, Terra Karana, the ninja meet a non-player character (NPC) called Okino, who helps them through many deadly challenges.

[N 9] The yellow Key-Tana is obtained by winning the Speedway Five-Billion, a dangerous race in the second game zone, Terra Technica.

[N 11] Lloyd, Jay and Nya continue their journey to obtain the final Key-tana in the third game zone, Terra Domina.

Zane is forced to give the Prime Empire motherboard to the Mechanic, who uses it to create a portal from the game into the real world.

In 2021, Prime Empire received three nominations in the Animation Series category of the Leo Awards for Best Art Direction, Sound, and Voice Performance.