The series occurred in the future, involving a war in which three star-faring civilizations are being invaded by the alien and seemingly mindless Mellenares, huge green killing machines traveling in a straight line and destroying everything in their path.

The brunt of the human defenses are giant, fusion-powered robots ("battle suits") called "Dynamo Class Robosoldiers" and crewed by living individuals.

Dynamo Joe focuses on the crew of one such suit: Imperium soldier Elanian Daro and Tavitan (humanoid feline) mechanic Pomru Purrwakkawakka, and their critical contributions to the war effort.

The back-up shorts found in MARS comic issues #10-12 were reprinted (with additional pages added) in "Dynamo Joe Special #1".

Dynamo Joe was supposed to be a three-issue limited series, but ended up running for 15 issues, reaching a sort of resolution before cancellation.

Pomru Purrwakkawakka was given great leniency in modifying the Dynamo Joe battlesuit and was known for pilfering objects and performing frequent modifications, despite the fact that he had clearance to nearly anything he wanted.

Dynamo Joe was the most advanced robosoldier suit on the front line as a result of his ongoing upgrades, many of which were derived from observing/studying the extra-dimensional, sentient battlesuit "Wolf-1", which was operated by a mercenary from the pan-dimensional city of Cynosure.

The Earth-based human culture was delineated by Earth-colonized worlds, held together by interstellar travel utilizing hyperspace, and the "Blood Nations", consisting of the Native American diaspora to the stars.

Upon contact with the planet eating Mellenares the Blood Nations reached an uneasy alliance with the Earth military forces and joined in combat against the mutual enemy.