Dynorphin A is a dynorphin, an endogenous opioid peptide that activates the κ-opioid receptor.

[2] Its amino acid sequence is Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys, a tridecapeptide.

[3][4] Dynorphin A1–8 is an agonist at the mu-, kappa-, and delta-opioid receptors;[4] it has the highest binding affinity for the kappa-opioid receptor.

[4] Structures of dynorphin A bound to the κ-opioid receptor have been reported.

[2][5] This article about an organic compound is a stub.