[1] It is the most commonly used letter in many languages, including Czech, Danish, Dutch, English, French, German, Hungarian, Latin, Latvian, Norwegian, Spanish, and Swedish.

This in turn comes from the Semitic letter hê, which has been suggested to have started as a praying or calling human figure (hillul, 'jubilation'), and was most likely based on a similar Egyptian hieroglyph that indicated a different pronunciation.

Although Middle English spelling used ⟨e⟩ to represent long and short /e/, the Great Vowel Shift changed long /eː/ (as in me or bee) to /iː/ while short /ɛ/ (as in met or bed) remained a mid vowel.

In the orthography of many languages, it represents either [e], [e̞], [ɛ], or some variation (such as a nasalized version) of these sounds, often with diacritics (as: ⟨e ê é è ë ē ĕ ě ẽ ė ẹ ę ẻ⟩) to indicate contrasts.

Less commonly, as in French, German, or Saanich, ⟨e⟩ represents a mid-central vowel /ə/.