[2] Daily is best known for her animation voice roles as Tommy Pickles on Rugrats and its spin-off All Grown Up, Buttercup on The Powerpuff Girls, Rudy Tabootie on ChalkZone, and Julius on Julius Jr. She also voiced the title character in the live-action film Babe: Pig in the City, Bamm-Bamm Rubble in the live-action film The Flintstones, and Froggy in The Little Rascals.

Daily is also known for her roles in a variety of live-action films such as Valley Girl, Dogfight, No Small Affair, Fandango, Streets of Fire, The Devil's Rejects, My Sister's Keeper, and Pee-wee's Big Adventure.

As a singer, Daily has released four studio albums: Wild Child (1985), Lace Around the Wound (1989), Tearing Down the Walls (1999), and Changing Faces (2008).

Daily has voiced animated characters such as Tommy Pickles in Rugrats, a role that she reprised for its revival on Paramount+,[3][4] and Freefall / Roxy Spaulding in the film Gen13 and Private Isabel "Dizzy" Flores in Roughnecks: Starship Troopers Chronicles.

She provided the voice for the lead role in the live-action feature film Babe: Pig in the City, replacing Christine Cavanaugh.

[7] Daily signed with A&M Records in 1985, working with Madonna's frequent collaborators John "Jellybean" Benitez and Stephen Bray.

Those same songs were later included in the lineup of fictional radio station Flashback 95.6 FM in the Grand Theft Auto III video game.

In her 1989 song, "Some People", from her Lace Around the Wound album, produced by Lotti Golden and Tommy Faragher, she plays guitar and harmonica.

She subsequently spent a short time living with her Valley Girl co-star Deborah Foreman for emotional support.