The gameplay is similar to Nintendo's 2003 game Mario Kart: Double Dash, but the characters and racetracks are all from six of Cartoon Network's original animated television series: Courage the Cowardly Dog, Cow and Chicken, Dexter's Laboratory, I Am Weasel, Johnny Bravo, and The Powerpuff Girls.

There are two characters the player must choose: a driver, who drives a go-kart, and a co-driver, who uses all weapons and has two "toon powers".

The karts have three stats: acceleration, speed, and handling (if chosen as driver).

If co-driver, they have two toon powers that fall into four categories: Shield, Attack, Boost and Flight.

[9][10] Lucas M. Thomas of IGN criticized the DS version for its similarities to the Mario Kart series, especially Mario Kart DS, as well as for having no characters from other Cartoon Network shows that were airing new episodes at the time.