Ezra Frank Sperry (June 18, 1843 – August 13, 1916) was an American politician who served as the 21st mayor of Orlando, Florida, from 1913 to 1916.

E. Frank Sperry was born in Bethany, Connecticut, on June 18, 1843.

He worked as a grocery clerk before starting his own company, Sperry Manufacturing.

[1] He moved to Orlando in 1882 and organized the South Florida Foundry and Machine Works.

He died in office from Bright's disease on August 13, 1916, at the age of 73.