The Chief Minister of Tamil Nadu, J. Jayalalithaa, appointed E. Gayathri as Honorary Director of Tamil Nadu Government Music Colleges in Chennai, Thiruvaiyaru, Madurai and Coimbatore in 2011.

Gayathri first trained under her parents and later under Sangita Kalanidhi T. M. Thyagarajan,[5] a Carnatic vocalist and composer.

Gayathri began her career at the age of 9 when Sri Parthasarathy Swami Sabha, Triplicane invited her to perform in their Saint Thyagaraja Festival in 1968.

Gayathri went on to receive awards and titles from organisations in India and abroad.

She was appointed as Honorary Director of Tamil Nadu Government Music Colleges (in Chennai, Thiruvaiyaru, Madurai and Coimbatore) by the Chief Minister of Tamil Nadu, J. Jayalalithaa, in 2011.