Enoch Walter Sikes (May 19, 1868 – January 8, 1941) was an American college football player and coach, professor, state senator, and university president.

He served as the head football coach at Wake Forest University from 1891 to 1893, compiling a record of 6–2–1.

Sikes taught history and political economics at Wake Forest from 1897 to 1916.

He served one term in the North Carolina Senate, representing Wake County in 1911.

This biographical article relating to a college football coach first appointed in the 1890s is a stub.