Mark Bernard Hardin (1838-1916) was an American chemist and professor who served as acting president of Clemson College (now University) in 1897, 1899, and 1902.

He studied science at the Virginia Military Institute, and remained there after graduation, becoming assistant commandant of cadets and an adjunct professor of chemistry, mineralogy, and geology.

Before students were enrolled in the school, his duties were to oversee the construction of the chemical laboratory, develop the chemistry curriculum, and inspect fertilizers as part of the college's extension system.

Hardin was chosen as acting president of the college in 1897 following the resignation of Edwin Boone Craighead, serving for one month until Henry Simms Hartzog arrived on campus.

Clemson's original chemistry building (which now houses humanities) was named in his honor, and his home on campus has been maintained for use by visiting trustees.