On television, he began in the BBC sitcom In Sickness and in Health (1985–1987), the ITV crime dramas The Bill (1988–1989) and Supply & Demand (1998), and the HBO series Oz (1997–2003), for which he won a CableACE Award.
He attended Hungerford School in Islington[5] and began studying social work at the Polytechnic of North London.
Also that year, he was cast in the role of Winston, a black, gay, council carer and a thorn in Alf Garnett's side, for series 1–3 of In Sickness and in Health on BBC1.
His first film role came in 1991, playing Carlton in Young Soul Rebels about the interaction between different youth cultural movements in late 1970s Britain.
The same year he won the major role of Kareem Saïd on the American television drama series Oz on HBO in the United States.
Walker spent time at a mosque in Harlem doing research on the Nation of Islam and American Muslim culture, explaining "As an actor, my portrayal had to be real.
And from March 2005 he made his debut on Broadway, playing Mark Antony in Julius Caesar at the Belasco Theatre in midtown-Manhattan alongside Denzel Washington as Marcus Brutus.
[9] Then in 2008 he was in the second episode of the BBC drama series Bonekickers, playing Senator Joy, a United States Presidential candidate.
In October 2008 he performed on BBC Radio 4 in the first adaptation of Alice Walker's 1982 epistolary novel The Color Purple in the UK, serialised in ten parts.
[11] In 2020, Walker stars as the lead in Steppenwolf Theatre Company's production of Between Riverside and Crazy by Stephen Adly Guirgis.
[12][13] In October 2020 Eamon appeared on portrait artist of the year UK[14] Walker lives in the United States with his wife Sandra.