The expressway designation begins several blocks later as Earhart Boulevard transitions into a limited-access freeway after crossing Hamilton Street.

The only full interchange along the route occurs at (South) Clearview Parkway (LA 3152), a north-south thoroughfare which connects the Huey P. Long Bridge with U.S. 61 and I-10.

Excepting the full interchange at Clearview Parkway, exits only occur from the westbound lanes, and marked on-ramps only serve the eastbound direction.

(An unmarked on-ramp enters the westbound lanes from L&A Road behind the Kansas City Southern railroad yard).

Earhart Expressway is used as a relatively uncongested route for commuters, as well as an alternate to I-10 or Airline Drive to reach Louis Armstrong New Orleans International Airport.