East Branch Fishing Creek primarily flows in a largely westward direction, from its source at State Game Lands #13, slightly west of Ricketts Glen State Park, to its mouth slightly north of Grassmere Park.

It starts flowing southwards for approximately one mile before picking up Heberly Run, its longest tributary.

[2][3] The total elevation change between East Branch Fishing Creek's source and its mouth is 1,500 feet (460 m).

[2] During a study of the waters of East Branch Fishing Creek and its tributaries, no stream miles in the watershed have been rated as very good.

[2] East Branch Fishing Creek receives an average of 39.16 tons of calcium carbonate per year.

The Huntley Mountain Formation occurs in the southeastern part of the watershed, as well as on most of the main tributaries of the creek.

These include the Dystrochrepts/Deep-Wellsboro-Oquaga, the Oquaga, the Lackawanna, the Lackawana-Oquaga, the Wellsboro, the Barbour, the Morris, the Norwich, the Udifluvents, and the Basher.

[2] The Dystrochrepts/Deep-Wellsboro-Oquaga soil association occurs in close proximity to East Branch Fishing Creek and its tributaries themselves.

The Lackawanna soil association occurs in the southern part of the watershed, starting just below Blackberry Run's confluence with East Branch Fishing Creek.

The Udifluvents soil association occurs near the confluence of Heberly Run and East Branch Fishing Creek.

[2] The watershed of East Branch Fishing Creek is entirely within the boundaries of Sullivan and Columbia Counties.

[2] One of the first settlers in the vicinity of East Branch Fishing Creek was Thomas Fritz, who arrived there in 1795 from Philadelphia.

[5] In 1864, a group of Union Army troops searched for deserters and draft evaders in East Branch Fishing Creek.

[8] 23.8 of the stream miles in East Branch Fishing Creek's watershed are a high-quality cold-water fishery.