The East End region offers a more secluded character and less population density than the Charlotte Amalie, Southside, and Tutu subdistricts.

East End is home to many of the islands' largest resorts, in addition to many shopping areas and entertainment venues, as well as the Coral World Marine Park & Underwater Observatory in Coki Point, which is the most popular tourist attraction on St. Thomas.

[3] East End is located about 7.4 miles (11.9 km) east of the territorial capital of Charlotte Amalie, which is approximately a 30-minute drive on the windy, small, and narrow St. Thomas roads.

East End resorts are therefore generally more expensive than those found elsewhere on the island.

The 20-minute ferry ride to Cruz Bay on the island of St. John, which is a part of the Virgin Islands National Park, leaves the town of Red Hook.