It is a large residential area with a commercial strip along East Monument Street.

The residential area is composed primarily of rowhouses that were developed, beginning in the 1870s, as housing for Baltimore's growing Bohemian (Czech) immigrant community.

The Bohemian National Parish of the Roman Catholic Church, St. Wenceslaus, is located in the neighborhood.

The folk art of screen painting is said to have originated in the neighborhood, at a produce store located at North Collington and Ashland Avenues.

[5] By 1969, the Czech-American community in Little Bohemia was predominantly composed of aging homeowners who lived alongside more recently arrived African-American residents.