East Prairie is a city in Mississippi County, Missouri, United States.

A post office called East Prairie has been in operation since 1872.

[7] The current town, which lies about a mile south of the original post office site, was established in 1883 as a stop along the St. Louis Southwestern Railway ("Cotton Belt"), and was originally known as "Hibbard".

[9] As its name indicates, the city lies in the eastern portion of a lowland area that extends from the Ozark Highlands to the Mississippi River, covering much of the Bootheel.

The small city of Anniston is located just northeast of East Prairie.

[11] According to the U.S. Census Bureau, East Prairie has a total area of 1.25 square miles (3.24 km2), all land.

29.7% of all households were made up of individuals, and 14.6% had someone living alone who was 65 years of age or older.

28.9% of all households were made up of individuals, and 15.2% had someone living alone who was 65 years of age or older.

[17] Media related to East Prairie, Missouri at Wikimedia Commons