Wilson City is a village in Mississippi County, Missouri, United States.

[3] Wilson City was one of several villages constructed in the early 1940s as part of the "Delmo Project", an initiative by the Farm Security Administration to aid displaced tenant farmers.

U.S. Route 62 connects Wilson City with Charleston, the county seat, to the west and Cairo, Illinois, to the northeast.

[7] According to the U.S. Census Bureau, Wilson City has a total area of 0.08 square miles (0.21 km2), all land.

The racial makeup of the village was 2.61% White and 97.39% Black or African American.

About 37.5% of families and 39.5% of the population were below the poverty line, including 28.8% of those under the age of eighteen and 71.0% of those 65 or over.