The hospital and its affiliates, including numerous pediatric physician practices, employ about 1,800 individuals in full-time, part-time and as-needed positions.

Later in 1975, the addition of an Intensive Care Nursery increased total beds at East Tennessee Children's Hospital to 122.

[2] Also in 2001 Children's Hospital announced plans for a major expansion and renovation project on the main campus.

[2] In 2006, the hospital provided surgical care to two Iraqi girls brought to the United States for treatment of serious medical conditions.

In the fall of 2008, Children's Hospital launched the community-wide Knoxville Area Coalition on Childhood Obesity to increase awareness of problems of childhood obesity, begin a community assessment of current initiatives and introduce the concept of a community coalition using the National Institutes of Health's We Can!

In the summer of 2008, Children's Hospital became the lead organization for Safe Kids of the Greater Knox Area.

The mission of the local Safe Kids coalition is to reduce unintentional injuries in children up to age 14 in the East Tennessee region by promoting awareness and implementing prevention initiatives.

Children's Hospital provides staff, volunteers, in-kind services (such as meeting space) and/or financial support to many community organizations whose goals are to improve the lives of children, including American Cancer Society, American Heart Association, CoverKids, CureFinders, Cystic Fibrosis Foundation, Down Syndrome Awareness Group, Dream Connection, Girls on the Run, Juvenile Diabetes Research Foundation, Knox County Health Department, Knox County Schools' Partners in Education, Knoxville Area Pregnancy Prevention Initiative, Knoxville Police Department's Safety City, Knoxville Police Department's Think Fast Alcohol Awareness Program, Leukemia and Lymphoma Society, March of Dimes, Montgomery Village, Smoke-Free Knoxville, TENNder Care Coalition and United Way.

Children's Hospital sponsors the Healthy Kids Community Education Program to provide classes for non-health care professionals.