The Foundation provides information about cystic fibrosis and finances CF research that aims to improve the quality of life for people with the disease.

[9][10] In April 2022, the Foundation announced a $5 million investment to life science treatment company Sionna Therapeutics, for the development of a new cystic fibrosis transmembrane conductance regulator (CFTR) modulators, a type of therapy that treats the underlying cause of CF.

[13] The Foundation is devised into many different departments including Public Policy and Advocacy, Communications, and Fundraising.

The list of national events includes Ultimate Golf Experience, American Airlines Celebrity Ski, and Volunteer Leadership Conference.

[17] The purpose of making the event virtual was to address the concerns of potential cross-infection among people living with cystic fibrosis who interact in person.

[18] Since the first BreatheCon, the Foundation has hosted several other virtual events dedicated to connecting the community, including FamilyCon and ResearchCon.