After his high school career ended, St. Claire attended Colgate University, where he was a star player.

After a long minor league career, St. Claire was traded by Pittsburgh to the Boston Braves as part of a minor league working agreement so that he could tutor young pitchers in the Braves organization.

On February 1, 1954, St. Claire was traded by Milwaukee with Johnny Antonelli, Billy Klaus, Don Liddle, and $50,000 to the New York Giants for Bobby Thomson and Sam Calderone.

After spending much of this season in the minor leagues, St. Claire was released from his contract and never played professional baseball again.

His son Randy St. Claire played for five Major League clubs between 1984 and 1994, and later became a pitching coach.