[1] Previously near the Christiansborg Castle at a hamlet called Osu Amanfong, where a commemorative monument now stands, the church relocated northwards to its present location near the Salem School when a new chapel was constructed and consecrated in 1902.

[1] In the subsequent two hundred and fifty years, activities of a few missionary societies including the French Capuchin Franciscans based in Axim and Komenda, the Moravian Mission in Accra and Elmina as well as the Society for the Propagation of the Gospel in Foreign Parts in Cape Coast yielded negligible outcomes in the hinterlands.

[4][5] Founded in 1815 in Basel, Switzerland at the height of the Pietist theological movement, many of its young missionaries came from working class artisan backgrounds in Wurtemberg located in southern Germany.

It aimed at expressing their Christian convictions through positive deeds and exemplary life-styles including spreading the Gospel to other continents in response to the ‘call of God’.” In their view, formal education, agriculture, small scale industry, arts and craft went hand in hand with the propagation of the Gospel.

[1][4][6][7][8] Several European communities from the United Kingdom, Denmark and the Netherlands had an established presence on the coast where trade and commerce flourished.

[1][9] The founding schoolmasters were the Americo-Liberian, George Thompson as well the West Indian Moravian missionaries, Alexander Worthy Clerk and Angolan-born, Catherine Mulgrave who were working under the auspices of the Basel Mission.

[1][9] The natives of Osu, La and Teshie refused to pay the new tax imposed and in 1854, the British bombarded the township with their warship, the “H.

[1][9] The mud huts were reduced to rubble and several inhabitants relocated to the hinterland plains beneath the Akwapim ridge.

For security reasons, the British colonial administration bought the surrounding huts and land around the castle and converted it to a botanical garden.

[1] In 1898, the church acquired a plot of land north of the Osu coast in a central part of the town that was easily accessible by the Christian locals and distant from the ocean.

[1] The African civil servants working at the seat of government pledged to contribute a sum of DM 200 monthly until the completion of the chapel building but payments were irregular.

[1] The decision by the Basel Mission to use money from the Poor Fund was based on the fact that several congregants were involved in trade or worked in the colonial civil service and had a relatively high standard of living.

[1] Funds had always been raised locally in the mission stations but the committee waived the rule due to the enthusiastic engagement of native congregants which was appreciates by member of the Osu church.

[1] Epting had to divide his time between Accra and Kumasi where the renovation of the Basel Mission House was taking place.

[1] The wooden super-structure to support the roofing tiles was firmly put in place and the walls of the chapel were completed.

[1] Affixed to the pulpit was an inscription on ebony wood taken from Psalm 119 verse 105 (KJV): “Thy word is a lamp unto my feet, and a light unto my path” with a black cross engraved above it.

The altar was jointly designed by Bannerman and Epting but paid for by the Basel Mission pastor and historian, Carl Christian Reindorf.

On Friday 17 October 1902, a Cement Tablet which is still in position today, was placed in the space above the main Entrance of the Church, bearing the inscription: "EBEN-EZER 1902 1 Sam 7: 12" The stone tablet inscription is a biblical reference to 1 Samuel 7:12 (NIV), "Then Samuel took a stone and set it up between Mizpah and Shen.

[1] The ministers of the church were followed by Presbyters, primary and middle school children and the teeming masses of Christians from the Osu community.

[1] Karl Epting gave the introductory speech at the entrance before handing over the keys of the church to the most senior missionary at the time, Michael Seeger.

[1] Per the Basel Report of the Dedication of the new church, Seeger made an appeal to friends in Basel for the donation of certain items of equipment and adornment for the new Church, explaining, “We are soliciting these from friends and well-wishers in our (home) country because our own members are now saddled with such a heavy debt due to the cost of the building that they will not be able to provide the money for them at the present time”.

On the occasion of the Golden Jubilee of Osu Eben-Ezer Chapel building in 1952, the Architect and Builder, Karl Epting, then an old man in Basel, recalled in a congratulatory message:[1]“I look back with joy upon [the] ten years during which I was privileged to work in the Gold Coast.

[1] Within the main sanctuary, there are commemorative plaques to honour the early Basel and West Indian missionaries, the pioneer pastor-historian, Carl Christian Reindorf as well as other notable Presbyterian ministers of Osu and Emmanuel Charles Quist, the first Speaker of the Parliament of Ghana.

[1] There are several groups in the church which is common to the Presbyterian denomination: Young People's Guild (YPG), Young Adults’ Fellowship (YAF), Men's and Women's Fellowships, Bible Study and Prayer Group (BSPG), Children's Service, Boy's and Girl's Brigades, Junior Youth (JY), the Church Choir, Singing Band, the Ebenezer Melody Band and the International Bible Reading Association (IBRA).