He graduated from Yale in 1718 and the following year relocated to Huntington in Suffolk County, New York to become assistant to a Reverend there.
Prime married three times: Margaret Sylvester in 1723, Experience Youngs in 1730, and Hannah Platt in 1752.
As Reverend, he published multiple discourses and a sermon, oftentimes embracing peculiar views.
Despite his Congregationalist education, Prime joined the other churches of Suffolk County in making the switch to Presbyterianism, becoming the moderator of the newly formed Presbytery.
Thereby expelled from his home church, he spent the rest of his life preaching in private residences in his parish.