He was the son of Edmund Sibly and Mary Larkholm, born in the parish of Cripplegate ward, London.
In 1790 he was temporarily in Ipswich, supporting Sir John Hadley D'Oyly, the Whig member, at the general election.
[3] Sibly is celebrated for the natal horoscope he cast of the United States of America, published in 1787 and is still cited.
[9] It has been said that experts of the time would have seen that Sibly was not very discriminating about the sources he chose, and drew on unpublished translations that he had borrowed.
[14] Revised editions appeared posthumously as Astrology, A New and Complete Illustration of the Occult Sciences by Ebenezer Sibly, M.D.
[15] The original version of Culpeper's English Physician and Complete Herbal was published in 1652 without illustrations.