In December 2015, Guinea was declared free of Ebola transmission by the U.N. World Health Organization,[3] however further cases continued to be reported from March 2016.

[5] Researchers from the Robert Koch Institute believe that the index case was a one or two-year-old boy who lived in the remote village of Meliandou, Guéckédou located in the Nzérékoré Region of Guinea.

[10][11] It is believed the Ebola virus later spread to the villages of Dandou Pombo and Dawa, both in Guéckédou, by the midwife who attended the boy.

[16] In August, Guinea's President Alpha Conde declared a national health emergency due to the outbreak.

Previous Ebola outbreaks had occurred in remote areas making containment easier; the West African outbreak struck in an area that lies at the centre of both a highly-mobile and densely populated region which made tracking more difficult: "This time, the virus is traveling effortlessly across borders by plane, car and foot, shifting from forests to cities and springing up in clusters far from any previously known infections.

Riots broke out in the regional capital, Nzérékoré, when rumors were spread that people were being contaminated when health workers were spraying a market area to decontaminate it.

Seeing workers wearing the required protection outfits worn by health workers and taking those suspected of having Ebola or of being contacts to the treatment center (perhaps never to be seen again), refusing the usual burial rituals when a patient died, and other actions taken by the unfamiliar individuals that had come to their remote areas, had led to rumors of organ harvesting and government and tribal plots.

According to a September news report, "Many Guineans say local and foreign healthcare workers are part of a conspiracy which either deliberately introduced the outbreak, or invented it as a means of luring Africans to clinics to harvest their blood and organs.

The team consisted of Guinean health and government officials accompanied by journalists, who had been distributing Ebola information and doing disinfection work.

[22][23][24] The governor of Conakry, Soriba Sorel Camara, prohibited all cultural events for the holiday of Tabaski in a decree of 2 October 2014.

One facility admitted 22 patients in a single day (6 October), 18 of them coming from Coyah region, 50 kilometres (31 miles) east of Conakry.

According to a WHO report, this new development highlights the need for increased surveillance of cross border traffic in an effort to contain the disease to the three most affected countries.

[29] On 23 October, Saccoba Keita, the head of Guinea's Ebola mission, announced the government has started compensating the families of health care workers who died after contracting the virus.

[31] On 20 November, the local Red Cross in Kankan Prefecture sent blood samples via a courier when the taxi he was traveling in was stopped by robbers.

[34] Guinea was subsequently in a 90-day period of heightened surveillance according to the U.N. World Health Organization which also offered assistance[3] - with funding from the agency's donors.

[46] This confirmed the results of a study published in 2015 that awarded the vaccine 100 percent effectiveness after tests on 4000 people in Guinea who had been in close contact with Ebola patients.

[47] In particular, the authors criticized the methodology of the patient trail, and argued that the protection provided by the vaccine may be lower than officially announced.

[48][49] It was announced in May 2017 that the Gamaleya Research Institute of Epidemiology and Microbiology in Russia would deliver 1000 doses of an independently produced vaccine to Guinea for testing.