Echinocereus santaritensis is a species of cactus native to Mexico and the United States.

[2] Echinocereus santaritensis is a multistem columnar cactus that branches from the base.

Chromosome count is 2n=44[3] This species is distinguished by its perfect flowers, 5 cm long styles, and areoles with hairs.

[4] Accepted subspecies:[5] This species is found growing on rocky slopes and outcrops in southern Arizona in the Little Ajo Mountains and Tucson Mountains, New Mexico and Mexico in Sonora and Chihuahua above 1070 meters growing along Juniperus arizonica and Vauquelinia californica.

[4] Echinocereus santaritensis was first described as in 1998 from plants collected in the Santa Rita Mountains.