Edward Lloyd Klepfer (March 17, 1888 – August 9, 1950) was an American spitball pitcher in Major League Baseball who played for the New York Yankees, Chicago White Sox and Cleveland Indians in a span of six seasons between 1911 and 1919.

Klepfer, commonly known as "Big Ed", was born on March 17, 1888, in Summerville, Pennsylvania.

He batted and threw right-handed and was also 6 ft 0 in (1.83 m), 180 pounds, and attended Penn State University.

His career was chopped up due to time spent fighting in World War I, as part of the American Expeditionary Forces in France.

On August 21, 1915, the White Sox traded Klepfer along with Larry Chappell, Braggo Roth and cash for Shoeless Joe Jackson.