Edward Rell "Ed" Madigan (January 13, 1936 – December 7, 1994) was a businessman and a Republican Party politician from Lincoln, Illinois.

He served almost twenty years in the United States House of Representatives and was U.S. secretary of agriculture under President George H. W. Bush.

Madigan narrowly lost the race for minority whip in 1989 to future Speaker of the House Newt Gingrich of Georgia.

He joined the company after his tenure as U.S. Secretary of Agriculture and served as the Senior Vice President for Government Affairs.

His role involved handling government relations and navigating the regulatory landscape for Philip Morris during a period of significant change and expansion.