Regarded as one of the best blocking wide receivers of all time, McCaffrey is a three-time Super Bowl champion (XXIX, XXXII, XXXIII), a second-team All-Pro selection in 1998, and a member of the Broncos' 50th anniversary team.

He earned first-team All-America and All-Pac-10 Conference honors as a senior in 1990, catching 61 passes for 917 yards and eight touchdowns that season.

[citation needed] McCaffrey entered the 1991 NFL draft and was selected by the New York Giants in the third round (83rd overall).

With the Denver Broncos, he became a reliable target for quarterback John Elway, set a Broncos record for most receptions in a season at the time with 101 receptions in the 2000 season, and had an exceptional performance in Super Bowl XXXIII against the Atlanta Falcons, recording five catches for 72 yards.

In 2000, McCaffrey and teammate Rod Smith became only the second wide receiver duo from the same team to each gain 100 receptions in the same season, matching a record by Herman Moore and Brett Perriman.

[6] During his tenure, he was known by the nicknames "Easy,"[7] “Eddie Mac,”[8] “White Lightning,”[9] and “The Bruise.”[10] McCaffrey was named the head football coach at Valor Christian High School in February 2018.

On July 30, 2012, McCaffrey was named the new color analyst for 850 KOA, flagship station of the Denver Broncos Radio Network, replacing Brian Griese.

Their eldest, Max, was a wide receiver who played college football for the Duke Blue Devils.

He was a running back for the Stanford Cardinal in 2014, 2015, and 2016, and was the runner-up for the 2015 Heisman Trophy behind Alabama's Derrick Henry in the 2015 voting.

[19] After graduating from Michigan in December 2020, he played one year at Northern Colorado and received his Master of Business Administration.