His paternal grandparents were Austrian Jewish refugees, from Vienna, who moved to England in the 1930s to escape the Nazis; his grandmother came over on the Kindertransport.

He has collaborated with a variety of artists including Foreign Beggars, Asian Dub Foundation, Plan B, Dubbledge and Doc Brown.

[16] In 2018, Skrein starred in psychological revenge thriller, In Darkness, alongside Natalie Dormer and Stacy Martin; principal photography began in early 2016.

[19][20][21] On 8 November 2019, he starred in Roland Emmerich’s blockbuster movie Midway, co-starring Mandy Moore, Patrick Wilson, Luke Evans, Aaron Eckhart, Nick Jonas, Dennis Quaid and Woody Harrelson.

[28][29] Leslie Felperin, writing for The Guardian, gave the film 3/5 stars, calling it a "sweet-natured but predictable comedy drama".

[30] Skrein wrote and directed the short drama film Little River Run (2020), which was released via his Instagram page.