Bill Monroe offered a job to Adcock in 1958, and he played with the Blue Grass Boys until he could no longer survive on bluegrass' declining pay due to the onslaught of Elvis Presley who cornered all music markets.

Then Charlie Waller and John Duffey asked Adcock to join their struggling new band, The Country Gentlemen, whereupon their vocal and instrumental synergy prompted a reinvention and elevation of their sound, soon revitalizing bluegrass music itself.

Eddie and Martha also founded and ran Adcock Audio, a large, state-of-the-art sound company, serving bluegrass-related festivals from the early 1970s until 2006, and from that time until the present have also recorded and produced themselves and others both outside and in-house at their own SunFall Studio.

[citation needed] This particular lineup, with Adcock serving as sparkplug, became known as the 'classic' Country Gentlemen, the team who drove the bluegrass sound and repertoire to new levels of experimentation, expertise, and excitement.

In addition, his driving, percussive and syncopated jazz-based single-string, soulful string-bending, and lush chordal approaches were at the heart of the group's new-form bluegrass instrumental style, as developed in the interplay between Adcock's mind-blowing fireworks-like innovations, Duffey's jazzy mandolin licks, and Waller's forceful guitar rhythm.

Returning east and forming II Generation, he met Martha Hearon[4] in 1973; they would marry three years later and have remained partners in music and life, garnering fans and great acclaim while touring worldwide in nearly a dozen countries from Europe to Japan.

[citation needed] Eddie and Martha, AKA The Adcocks, have appeared on Austin City Limits, Song of the Mountains, Grassroots to Bluegrass, Ernest Tubb's Midnite Jamboree, TNN's 'Nashville Now' and Wildhorse Saloon, and a host of NPR specials, as well as syndicated, Internet, and local TV and radio shows worldwide.

In October 2008, concerns about hand-tremors, which could have compromised his performing career, led to Adcock having deep brain stimulation (DBS) surgery at Vanderbilt University Medical Center.