Coming directly out of Thornwood High School in South Holland, Illinois, Curry was selected fourth overall in the 2001 NBA draft by the Chicago Bulls.

In 2001, Eddy Curry and four other high school basketball stars, were the subject of the documentary "Preps:Chicago Hoops", a series about making the jump to college or the NBA.

[5] Curry had signed a letter of intent to play at DePaul University but declared himself eligible for the 2001 NBA draft in which the Chicago Bulls made him the fourth overall pick.

In the 2004–05 season the Bulls improved by 28 wins and made the playoffs as the 22-year-old Curry led the team in scoring before being hospitalized with an irregular heartbeat.

On October 3, 2005, after refusing on privacy grounds to submit to a DNA test, as requested by Bulls management, to assess whether he has a congenital heart condition, Curry was traded to the New York Knicks.

The trade included the Bulls' Antonio Davis, as well as the Knicks' Mike Sweetney, Tim Thomas, and Jermaine Jackson.

Curry's inability to defend and rebound was a source of frustration for former coaches Scott Skiles and Larry Brown.

On April 7, 2007, Curry scored a career-best 43 points in an overtime win over the Milwaukee Bucks; his first three-pointer of the season forcing the game into the extra period.

[8] In the 2007–2008 season, Curry was expected to form a great frontcourt with Zach Randolph, however both of them saw a regression in their games.

Curry showed up to training camp in October 2008 out of shape for the second year in a row, incensing new head coach Mike D'Antoni.

[9] On February 22, 2011, Curry was traded to the Minnesota Timberwolves in a three-way blockbuster deal which also involved Denver Nuggets that brought Carmelo Anthony to New York.

[18] He played two games for Dallas before being waived to make room for Troy Murphy, as the Mavericks wanted a power forward with outside shooting ability instead of a traditional center.

On December 6, 2012, Curry signed with the Zhejiang Golden Bulls in China, replacing Josh Boone.

Several prominent cardiologists cleared Curry to play,[26][27] but Barry Maron, a world-renowned specialist in hypertrophic cardiomyopathy, suggested a DNA test.